|
KMID : 0613820200300070634
|
|
Journal of Life Science
2020 Volume.30 No. 7 p.634 ~ p.639
|
|
|
Anti-inflammatory Effects of Heat-treated Starfish Extract in Lipopolysaccharide- stimulated RAW 264.7 Cells
|
|
Park Jae-Hyeon
Ahn Keun-Jae
Lee Sun-Ryung
|
|
|
Abstract
|
|
|
|
Starfish are a potential source of marine materials, but their unique odor can limit application. Our previous work suggested that brittle star Ophioplocus japonicus extract could be more effective as a cosmetic material by reducing its odor through a roasting process. However, the biological properties of heat-treated Ophioplocus japonicus extract (HOJE) remain poorly understood. We here examined the anti-inflammatory potential of HOJE in lipopolysaccharide (LPS)-induced RAW 264.7 cells. HOJE significantly inhibits LPS-stimulated nitric oxide (NO) production without affecting cell viability in a dose-dependent manner and suppresses LPS-induced expression of inducible nitric oxide synthases (iNOS) and pro-inflammatory cytokines such as interleukin-6 and -1β. Furthermore, treatment of pyrrolidine dithiocarbamate to inhibit nuclear factor kappa B (NF-κB) signaling accelerated the inhibitory effect of HOJE on NO production, and the translocation of NF-κB p65 from the cytosol to the nucleus was attenuated by HOJE. These results show that HOJE ameliorates inflammation partly through NF-κB signaling which consequently suggests that it has anti-inflammatory potential.
|
|
|
KEYWORD
|
|
|
Inflammation, NF-κB, NO, Ophioplocus japonicus, starfish
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|